Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture | Zendy

Zhengyu Cao | Zendy; Timothy J. Shafer | Zendy; Kevin M. Crofton | Zendy; Chris Gennings | Zendy; Thomas F. Murray | Zendy

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Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture

Author(s) -

Zhengyu Cao,

Timothy J. Shafer,

Kevin M. Crofton,

Chris Gennings,

Thomas F. Murray

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1003394

Subject(s) - pyrethroid , primary culture , primary (astronomy) , sodium , chemistry , pharmacology , neuroscience , toxicology , medicine , biology , biochemistry , in vitro , pesticide , physics , ecology , organic chemistry , astronomy

Pyrethroid insecticides bind to voltage-gated sodium channels and modify their gating kinetics, thereby disrupting neuronal function. Although previous work has tested the additivity of pyrethroids in vivo, this has not been assessed directly at the primary molecular target using a functional measure.

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