Benzo[a]pyrene Reduces Testosterone Production in Rat Leydig Cells via a Direct Disturbance of Testicular Steroidogenic Machinery | Zendy

Jin Yong Chung | Zendy; Yoon Jae Kim | Zendy; Ji Young Kim | Zendy; Seung Gee Lee | Zendy; JiEun Park | Zendy; Won Rok Kim | Zendy; YongDal Yoon | Zendy; Ki Soo Yoo | Zendy; Young Hyun Yoo | Zendy; JongMin Kim | Zendy

Open Access

Benzo[a]pyrene Reduces Testosterone Production in Rat Leydig Cells via a Direct Disturbance of Testicular Steroidogenic Machinery

Author(s) -

Jin Yong Chung,

Yoon Jae Kim,

Ji Young Kim,

Seung Gee Lee,

JiEun Park,

Won Rok Kim,

YongDal Yoon,

Ki Soo Yoo,

Young Hyun Yoo,

JongMin Kim

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1003391

Subject(s) - cholesterol side chain cleavage enzyme , steroidogenic acute regulatory protein , leydig cell , medicine , endocrinology , testosterone (patch) , pregnenolone , human chorionic gonadotropin , benzo(a)pyrene , androgen , chemistry , testicular atrophy , biology , luteinizing hormone , cytochrome p450 , carcinogen , gene expression , metabolism , hormone , steroid , biochemistry , gene

Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is a ubiquitous environmental pollutant that is currently suspected of being an endocrine disruptor. The testis is an important target for PAHs, yet insufficient attention has been paid to their effects on steroidogenesis in Leydig cells.

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