Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A | Zendy

Anne Riu | Zendy; Marina Grimaldi | Zendy; Albane le Maire | Zendy; Gilbert Bey | Zendy; Kevin J. Phillips | Zendy; Abdelhay Boulahtouf | Zendy; Elisabeth Perdu | Zendy; Daniel Zalko | Zendy; William Bourguet | Zendy; Patrick Balaguer | Zendy

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Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A

Author(s) -

Anne Riu,

Marina Grimaldi,

Albane le Maire,

Gilbert Bey,

Kevin J. Phillips,

Abdelhay Boulahtouf,

Elisabeth Perdu,

Daniel Zalko,

William Bourguet,

Patrick Balaguer

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1003328

Subject(s) - xenoestrogen , nuclear receptor , chemistry , bisphenol a , peroxisome proliferator activated receptor , receptor , endocrine disruptor , peroxisome , bisphenol , estrogen receptor , rosiglitazone , biochemistry , endocrine system , transcription factor , biology , hormone , genetics , gene , organic chemistry , cancer , breast cancer , epoxy

The occurrence of halogenated analogs of the xenoestrogen bisphenol A (BPA) has been recently demonstrated both in environmental and human samples. These analogs include brominated [e.g., tetrabromobisphenol A (TBBPA)] and chlorinated [e.g., tetrachlorobisphenol A (TCBPA)] bisphenols, which are both flame retardants. Because of their structural homology with BPA, such chemicals are candidate endocrine disruptors. However, their possible target(s) within the nuclear hormone receptor superfamily has remained unknown.

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