In Utero and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on Cyp1a2 and Ahr Genotypes | Zendy

Christine Curran | Zendy; Daniel W. Nebert | Zendy; Mary Beth Genter | Zendy; Krishna Patel | Zendy; Tori L. Schaefer | Zendy; Matthew R. Skelton | Zendy; Michael T. Williams | Zendy; Charles V. Vorhees | Zendy

Open Access

In Utero and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on Cyp1a2 and Ahr Genotypes

Author(s) -

Christine Curran,

Daniel W. Nebert,

Mary Beth Genter,

Krishna Patel,

Tori L. Schaefer,

Matthew R. Skelton,

Michael T. Williams,

Charles V. Vorhees

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002965

Subject(s) - offspring , in utero , genotype , biology , pregnancy , genetics , physiology , fetus , gene

Both coplanar and noncoplanar polychlorinated biphenyls (PCBs) exhibit neurotoxic effects in animal studies, but individual congeners do not always produce the same effects as PCB mixtures. Humans genetically have > 60-fold differences in hepatic cytochrome P450 1A2 (CYP1A2)-uninduced basal levels and > 12-fold variability in aryl hydrocarbon receptor (AHR)affinity; because CYP1A2 is known to sequester coplanar PCBs and because AHR ligands include coplanar PCBs, both genotypes can affect PCB response.

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