Environmental Exposures and Mammary Gland Development: State of the Science, Public Health Implications, and Research Recommendations | Zendy

Ruthann A. Rudel | Zendy; Suzanne E. Fenton | Zendy; Janet M. Ackerman | Zendy; Susan Y. Euling | Zendy; Susan L. Makris | Zendy

Open Access

Environmental Exposures and Mammary Gland Development: State of the Science, Public Health Implications, and Research Recommendations

Author(s) -

Ruthann A. Rudel,

Suzanne E. Fenton,

Janet M. Ackerman,

Susan Y. Euling,

Susan L. Makris

Publication year - 2011

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002864

Subject(s) - lactation , mammary gland , breast development , public health , risk assessment , animal studies , breast cancer , medicine , physiology , cancer , biology , pregnancy , pathology , endocrinology , hormone , genetics , computer security , computer science

Perturbations in mammary gland (MG) development may increase risk for later adverse effects, including lactation impairment, gynecomastia (in males), and breast cancer. Animal studies indicate that exposure to hormonally active agents leads to this type of developmental effect and related later life susceptibilities. In this review we describe current science, public health issues, and research recommendations for evaluating MG development.

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