Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations | Zendy

Michael J. Zuscik | Zendy; Lin Ma | Zendy; Taylor Buckley | Zendy; J. Edward Puzas | Zendy; Hicham Drissi | Zendy; Edward M. Schwarz | Zendy; Regis J. O’Keefe | Zendy

Open Access

Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations

Author(s) -

Michael J. Zuscik,

Lin Ma,

Taylor Buckley,

J. Edward Puzas,

Hicham Drissi,

Edward M. Schwarz,

Regis J. O’Keefe

Publication year - 2007

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.10028

Subject(s) - chondrogenesis , mesenchymal stem cell , wnt signaling pathway , microbiology and biotechnology , chemistry , signal transduction , creb , bone morphogenetic protein 2 , bone morphogenetic protein , biology , medicine , transcription factor , biochemistry , in vitro , gene

It has been established that skeletal growth is stunted in lead-exposed children. Because chondrogenesis is a seminal step during skeletal development, elucidating the impact of Pb on this process is the first step toward understanding the mechanism of Pb toxicity in the skeleton.

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