Moving Forward in Human Cancer Risk Assessment | Zendy

Richard S. Paules | Zendy; Jiri Aubrecht | Zendy; Raffaella Corvi | Zendy; Bernward Garthoff | Zendy; Jos Kleinjans | Zendy

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Moving Forward in Human Cancer Risk Assessment

Author(s) -

Richard S. Paules,

Jiri Aubrecht,

Raffaella Corvi,

Bernward Garthoff,

Jos Kleinjans

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002735

Subject(s) - risk assessment , risk analysis (engineering) , animal testing , medicine , microbiology and biotechnology , data science , computer science , biology , genetics , computer security

The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks.

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