Para- and Ortho -Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity | Zendy

Kyung Ho Kim | Zendy; Diptiman D. Bose | Zendy; Atefeh Ghogha | Zendy; Joyce Riehl | Zendy; Rui Zhang | Zendy; Christopher D. Barnhart | Zendy; Pamela J. Lein | Zendy; Isaac N. Pessah | Zendy

Open Access

Para- and Ortho -Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity

Author(s) -

Kyung Ho Kim,

Diptiman D. Bose,

Atefeh Ghogha,

Joyce Riehl,

Rui Zhang,

Christopher D. Barnhart,

Pamela J. Lein,

Isaac N. Pessah

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002728

Subject(s) - ryanodine receptor , ryr1 , polybrominated diphenyl ethers , chemistry , neurotoxicity , ryanodine receptor 2 , hek 293 cells , receptor , biochemistry , toxicity , organic chemistry , pollutant

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined.

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