Many Putative Endocrine Disruptors Inhibit Prostaglandin Synthesis
Author(s) -
David M. Kristensen,
Maria Lena Skalkam,
Karine Audouze,
Laurianne Lesné,
Christèle Lethimonier,
Hanne Frederiksen,
Søren Brunak,
Niels E. Skakkebæk,
Bernard Jégou,
Jacob B. Hansen,
Steffen Junker,
Henrik Leffers
Publication year - 2010
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1002635
Subject(s) - receptor , endocrine system , prostaglandin , enzyme , chemistry , signal transduction , nuclear receptor , in vivo , lipid signaling , hormone , biology , biochemistry , pharmacology , transcription factor , gene , microbiology and biotechnology
Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural similarity with mild analgesics.
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