RDX Binds to the GABA A Receptor–Convulsant Site and Blocks GABA A Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures | Zendy

Larry R. Williams | Zendy; Vassiliki AroniadouAnderjaska | Zendy; Felicia Qashu | Zendy; Huckelberry A. Finne | Zendy; Volodymyr I. Pidoplichko | Zendy; Desmond I. Ban | Zendy; Maria F. M. Braga | Zendy

Open Access

RDX Binds to the GABA _A Receptor–Convulsant Site and Blocks GABA _A Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures

Author(s) -

Larry R. Williams,

Vassiliki AroniadouAnderjaska,

Felicia Qashu,

Huckelberry A. Finne,

Volodymyr I. Pidoplichko,

Desmond I. Ban,

Maria F. M. Braga

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002588

Subject(s) - convulsant , dimethyl sulfoxide , dilution , chemistry , gabaa receptor , pharmacology , receptor , toxicity , medicine , biochemistry , organic chemistry , physics , thermodynamics

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high-energy, trinitrated cyclic compound that has been used worldwide since World War II as an explosive in both military and civilian applications. RDX can be released in the environment by way of waste streams generated during the manufacture, use, and disposal of RDX-containing munitions and can leach into groundwater from unexploded munitions found on training ranges. For > 60 years, it has been known that exposure to high doses of RDX causes generalized seizures, but the mechanism has remained unknown.

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