The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither? | Zendy

Peter W. Stacpoole | Zendy

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The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?

Author(s) -

Peter W. Stacpoole

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002554

Subject(s) - medicine , pharmacology , chemistry , toxicology , intensive care medicine , biology

Dichloroacetate (DCA) is known to environmental scientists as a by-product of water chlorination and as a metabolite of industrial solvents, including Superfund chemicals. In contrast, DCA is studied by clinical investigators for its therapeutic potential in several life-threatening conditions, including genetic mitochondrial diseases, pulmonary arterial hypertension, and cancer. Thus, DCA holds an almost unique position at the interface between environmental science and allopathic medicine.

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