Combinations of Physiologic Estrogens with Xenoestrogens Alter ERK Phosphorylation Profiles in Rat Pituitary Cells | Zendy

Yow-Jiun Jeng | Zendy; Cheryl S. Watson | Zendy

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Combinations of Physiologic Estrogens with Xenoestrogens Alter ERK Phosphorylation Profiles in Rat Pituitary Cells

Author(s) -

Yow-Jiun Jeng,

Cheryl S. Watson

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002512

Subject(s) - mapk/erk pathway , estrogen , estrogen receptor , medicine , xenoestrogen , endocrinology , gper , kinase , estriol , signal transduction , chemistry , endocrine system , biology , hormone , pharmacology , microbiology and biotechnology , cancer , breast cancer

Estrogens are potent nongenomic phospho-activators of extracellular-signal-regulated kinases (ERKs). A major concern about the toxicity of xenoestrogens (XEs) is potential alteration of responses to physiologic estrogens when XEs are present simultaneously.

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