Gene Expression Alterations in Immune System Pathways in the Thymus after Exposure to Immunosuppressive Chemicals | Zendy

Rachel P. Frawley | Zendy; Kimber L. White | Zendy; R. D. Brown | Zendy; D. L. Musgrove | Zendy; Nigel J. Walker | Zendy; Dori R. Germolec | Zendy

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Gene Expression Alterations in Immune System Pathways in the Thymus after Exposure to Immunosuppressive Chemicals

Author(s) -

Rachel P. Frawley,

Kimber L. White,

R. D. Brown,

D. L. Musgrove,

Nigel J. Walker,

Dori R. Germolec

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002358

Subject(s) - biology , immune system , t cell receptor , t cell , cd8 , immunology , microbiology and biotechnology

Dysregulation of positive and negative selection, antigen presentation, or apoptosis in the thymus can lead to immunosuppression or autoimmunity. Diethylstilbestrol (DES), dexamethasone (DEX), cyclophosphamide (CPS), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are immunosuppressive chemicals that induce similar immunotoxic effects in the thymus, however, the mechanism of toxicity is purported to be different for each compound.

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