Estrogenic Activity of Bisphenol A and 2,2-bis( p -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles | Zendy

Sylvia C. Hewitt | Zendy; Kenneth S. Korach | Zendy

Open Access

Estrogenic Activity of Bisphenol A and 2,2-bis( p -Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles

Author(s) -

Sylvia C. Hewitt,

Kenneth S. Korach

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002347

Subject(s) - bisphenol a , medicine , benzhydryl compounds , endocrinology , chemistry , andrology , organic chemistry , epoxy

Interest and concern regarding potentially estrogenic substances have resulted in development of model systems to evaluate mechanisms of such chemicals. Microarray studies have indicated that estradiol (E2)-stimulated uterine responses can be divided into early and late phases. Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds.

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