Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N -Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies | Zendy

Nilusha Ragunathan | Zendy; Julien Dairou | Zendy; Elodie Sanfins | Zendy; Florent Busi | Zendy; Christophe Noll | Zendy; Nathalie Janel | Zendy; JeanMarie Dupret | Zendy; Fernando RodriguesLima | Zendy

Open Access

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N -Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies

Author(s) -

Nilusha Ragunathan,

Julien Dairou,

Elodie Sanfins,

Florent Busi,

Christophe Noll,

Nathalie Janel,

JeanMarie Dupret,

Fernando RodriguesLima

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002334

Subject(s) - carcinogen , chemistry , biotransformation , xenobiotic , enzyme , arylamine n acetyltransferase , in vivo , biochemistry , toxicokinetics , acetylation , metabolism , biology , microbiology and biotechnology , gene

Cadmium (Cd) is a carcinogenic heavy metal of environmental concern. Exposure to both Cd and carcinogenic organic compounds, such as polycyclic aromatic hydrocarbons or aromatic amines (AAs), is a common environmental problem. Human arylamine N-acetyltransferases (NATs) are xenobiotic-metabolizing enzymes that play a key role in the biotransformation of AA carcinogens. Changes in NAT activity have long been associated with variations in susceptibility to different cancers in relation with exposure to certain AAs.

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