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Cadmium (Cd) is a carcinogenic heavy metal of environmental concern. Exposure to both Cd and carcinogenic organic compounds, such as polycyclic aromatic hydrocarbons or aromatic amines (AAs), is a common environmental problem. Human arylamine N-acetyltransferases (NATs) are xenobiotic-metabolizing enzymes that play a key role in the biotransformation of AA carcinogens. Changes in NAT activity have long been associated with variations in susceptibility to different cancers in relation with exposure to certain AAs.

environmental health perspectives

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine <i>N</i> -Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and <i>in Vivo</i> Studies

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N -Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies