Mechanisms of Diesel-Induced Endothelial Nitric Oxide Synthase Dysfunction in Coronary Arterioles | Zendy

Tom W. Cherng | Zendy; Michael L. Paffett | Zendy; Olan JacksonWeaver | Zendy; Matthew J. Campen | Zendy; Benjimen R. Walker | Zendy; Nancy L. Kanagy | Zendy

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Mechanisms of Diesel-Induced Endothelial Nitric Oxide Synthase Dysfunction in Coronary Arterioles

Author(s) -

Tom W. Cherng,

Michael L. Paffett,

Olan JacksonWeaver,

Matthew J. Campen,

Benjimen R. Walker,

Nancy L. Kanagy

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002286

Subject(s) - nitric oxide synthase , medicine , nitric oxide , vasodilation , coronary arteries , endothelial dysfunction , vasoconstriction , endocrinology , acetylcholine , superoxide , chemistry , cardiology , anesthesia , artery , biochemistry , enzyme

Increased air pollutants correlate with increased incidence of cardiovascular disease potentially due to vascular dysfunction. We have reported that acute diesel engine exhaust (DE) exposure enhances vasoconstriction and diminishes acetylcholine (ACh)-induced dilation in coronary arteries in a nitric oxide synthase (NOS)-dependent manner. We hypothesize that acute DE inhalation leads to endothelial dysfunction by uncoupling NOS.

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