HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study | Zendy

Aimin Zhang | Zendy; Sung Kyun Park | Zendy; Robert O. Wright | Zendy; Marc G. Weisskopf | Zendy; Bhramar Mukherjee | Zendy; Huiling Nie | Zendy; David Sparrow | Zendy; Howard Hu | Zendy

Open Access

HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study

Author(s) -

Aimin Zhang,

Sung Kyun Park,

Robert O. Wright,

Marc G. Weisskopf,

Bhramar Mukherjee,

Huiling Nie,

David Sparrow,

Howard Hu

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002251

Subject(s) - normative , lead exposure , pulse pressure , medicine , environmental health , gerontology , blood pressure , political science , cats , law

Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulative lead exposure on measures of adult cognition and cardiac function.

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