Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data | Zendy

David M. Reif | Zendy; Matthew T. Martin | Zendy; Shirlee Tan | Zendy; Keith A. Houck | Zendy; Richard Judson | Zendy; Ann M. Richard | Zendy; Thomas B. Knudsen | Zendy; David J. Dix | Zendy; Robert J. Kavlock | Zendy

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Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

Author(s) -

David M. Reif,

Matthew T. Martin,

Shirlee Tan,

Keith A. Houck,

Richard Judson,

Ann M. Richard,

Thomas B. Knudsen,

David J. Dix,

Robert J. Kavlock

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002180

Subject(s) - prioritization , endocrine disruptor , computational biology , xenobiotic , toxaphene , endocrine system , biology , computer science , bioinformatics , pesticide , hormone , engineering , ecology , biochemistry , management science , enzyme

The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery of 467 in vitro, high-throughput screening assays to assess 309 environmental chemicals. One important mode of action leading to toxicity is endocrine disruption, and the U.S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife.

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