Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation | Zendy

Tao Chen | Zendy; Angela Mally | Zendy; Sibel Özden | Zendy; James Kevin Chipman | Zendy

Open Access

Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation

Author(s) -

Tao Chen,

Angela Mally,

Sibel Özden,

James Kevin Chipman

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1002153

Subject(s) - dna methylation , epigenetics , biology , gene expression , dna damage , microrna , methylation , cell cycle , microbiology and biotechnology , gene , apoptosis , carcinogen , real time polymerase chain reaction , regulation of gene expression , dna , genetics

Evidence of potent rodent carcinogenicity via an unclear mechanism suggests that furan in various foods [leading to an intake of up to 3.5 microg/kg body weight (bw)/day] may present a potential risk to human health.

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