Estrogen-Like Effects of Cadmium in Vivo Do Not Appear to be Mediated via the Classical Estrogen Receptor Transcriptional Pathway
Author(s) -
Imran Ali,
Pauliina Damdimopoulou,
Sari Mäkelä,
Marika Berglund,
Ulla Stenius,
Agneta Åkesson,
Helen Håkansson,
Krister Halldin
Publication year - 2010
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.1001967
Subject(s) - estrogen receptor , in vivo , estrogen , endocrinology , mapk/erk pathway , biology , medicine , luciferase , ethinylestradiol , endocrine disruptor , signal transduction , kinase , protein kinase a , gper , microbiology and biotechnology , hormone , endocrine system , transfection , biochemistry , population , cancer , environmental health , research methodology , breast cancer , gene
Cadmium (Cd), a ubiquitous food contaminant, has been proposed to be an endocrine disruptor by inducing estrogenic responses in vivo. Several in vitro studies suggested that these effects are mediated via estrogen receptors (ERs).
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