Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh | Zendy

J. Richard Pilsner | Zendy; Megan N. Hall | Zendy; Xinhua Liu | Zendy; Habibul Ahsan | Zendy; Vesna Ilievski | Zendy; Vesna Slavkovich | Zendy; David E. Levy | Zendy; Pam FactorLitvak | Zendy; Joseph H. Graziano | Zendy; Mary V. Gamble | Zendy

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Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh

Author(s) -

J. Richard Pilsner,

Megan N. Hall,

Xinhua Liu,

Habibul Ahsan,

Vesna Ilievski,

Vesna Slavkovich,

David E. Levy,

Pam FactorLitvak,

Joseph H. Graziano,

Mary V. Gamble

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1001937

Subject(s) - urine , dna methylation , arsenic , liter , physiology , methylation , selenium , metabolite , whole blood , confounding , urinary system , confidence interval , medicine , toxicity , biology , chemistry , endocrinology , immunology , dna , genetics , gene , gene expression , organic chemistry

Global hypomethylation of DNA is thought to constitute an early event in some cancers and occurs in response to arsenic (As) exposure and/or selenium (Se) deficiency in both in vitro and animal models. In addition, antagonism between As and Se, whereby each reduces toxicity of the other, has been well documented in animal models. Se status may therefore modify the health effects of As in As-exposed populations.

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