Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice | Zendy

Doni Hikmat Ramdhan | Zendy; Michihiro Kamijima | Zendy; Dong Wang | Zendy; Yuki Ito | Zendy; Hisao Naito | Zendy; Yukie Yanagiba | Zendy; Yumi Hayashi | Zendy; Naoki Tanaka | Zendy; Toshifumi Aoyama | Zendy; Frank J. Gonzalez | Zendy; Tamie Nakajima | Zendy

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Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice

Author(s) -

Doni Hikmat Ramdhan,

Michihiro Kamijima,

Dong Wang,

Yuki Ito,

Hisao Naito,

Yukie Yanagiba,

Yumi Hayashi,

Naoki Tanaka,

Toshifumi Aoyama,

Frank J. Gonzalez,

Tamie Nakajima

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.1001928

Subject(s) - steatosis , medicine , endocrinology , peroxisome proliferator activated receptor , inflammation , peroxisome , hepatocyte , nuclear receptor , triglyceride , rosiglitazone , biology , chemistry , receptor , biochemistry , cholesterol , gene , in vitro , transcription factor

Trichloroacetic acid, an oxidative metabolite of trichloroethylene (TRI), is a ligand of the peroxisome proliferator-activated receptor alpha (PPAR) alpha, which is involved in lipid homeostasis and anti-inflammation.

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