Open AccessCadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells
Author(s) -
Patrizia Gena,
Giuseppe Calamita,
William B. Guggino
Publication year - 2010
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.0901874
Subject(s) - chemistry , cycloheximide , endocytosis , cadmium chloride , bafilomycin , mg132 , reabsorption , microbiology and biotechnology , biochemistry , kidney , receptor , endocrinology , proteasome , cadmium , biology , protein biosynthesis , proteasome inhibitor , autophagy , apoptosis , organic chemistry
Cadmium (Cd) is a potent nephrotoxicant that impairs the reabsorptive and secretory functions of the renal proximal tubule, leading to albuminuria.
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