Evaluation of Candidate Genes for Cholinesterase Activity in Farmworkers Exposed to Organophosphorus Pesticides: Association of Single Nucleotide Polymorphisms in BCHE | Zendy

Timothy D. Howard | Zendy; FangChi Hsu | Zendy; Joseph G. Grzywacz | Zendy; Haiying Chen | Zendy; Sara A. Quandt | Zendy; Quirina M. Vallejos | Zendy; Lara E. Whalley | Zendy; Wei Cui | Zendy; Stephanie Padilla | Zendy; Thomas A. Arcury | Zendy

Open Access

Evaluation of Candidate Genes for Cholinesterase Activity in Farmworkers Exposed to Organophosphorus Pesticides: Association of Single Nucleotide Polymorphisms in BCHE

Author(s) -

Timothy D. Howard,

FangChi Hsu,

Joseph G. Grzywacz,

Haiying Chen,

Sara A. Quandt,

Quirina M. Vallejos,

Lara E. Whalley,

Wei Cui,

Stephanie Padilla,

Thomas A. Arcury

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0901764

Subject(s) - single nucleotide polymorphism , cholinesterase , pesticide , gene , genetics , candidate gene , biology , toxicology , medicine , bioinformatics , pharmacology , genotype , agronomy

Organophosphate pesticides act as cholinesterase inhibitors. For those with agricultural exposure to these chemicals, risk of potential exposure-related health effects may be modified by genetic variability in cholinesterase metabolism. Cholinesterase activity is a useful, indirect measurement of pesticide exposure, especially in high-risk individuals such as farmworkers. To understand fully the links between pesticide exposure and potential human disease, analyses must be able to consider genetic variability in pesticide metabolism.

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