Polychlorinated Biphenyls Disrupt Intestinal Integrity via NADPH Oxidase-Induced Alterations of Tight Junction Protein Expression | Zendy

Yean Jung Choi | Zendy; Melissa J. Seelbach | Zendy; Hong Pu | Zendy; Sung Yong Eum | Zendy; Lei Chen | Zendy; Bei Zhang | Zendy; Bernhard Hennig | Zendy; Michał Toborek | Zendy

Open Access

Polychlorinated Biphenyls Disrupt Intestinal Integrity via NADPH Oxidase-Induced Alterations of Tight Junction Protein Expression

Author(s) -

Yean Jung Choi,

Melissa J. Seelbach,

Hong Pu,

Sung Yong Eum,

Lei Chen,

Bei Zhang,

Bernhard Hennig,

Michał Toborek

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0901751

Subject(s) - tight junction , occludin , caco 2 , intestinal permeability , nadph oxidase , chemistry , barrier function , microbiology and biotechnology , fluorescein isothiocyanate , biology , biochemistry , immunology , reactive oxygen species , in vitro , physics , quantum mechanics , fluorescence

Polychlorinated biphenyls (PCBs) are widely distributed environmental toxicants that contribute to numerous disease states. The main route of exposure to PCBs is through the gastrointestinal tract; however, little is known about the effects of PCBs on intestinal epithelial barrier functions.

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