Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress | Zendy

Jingqi Fu | Zendy; Courtney G. Woods | Zendy; Einav YehudaShnaidman | Zendy; Qiang Zhang | Zendy; Victoria Wong | Zendy; Sheila Collins | Zendy; Guifan Sun | Zendy; Melvin E. Andersen | Zendy; Jingbo Pi | Zendy

Open Access

Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress

Author(s) -

Jingqi Fu,

Courtney G. Woods,

Einav YehudaShnaidman,

Qiang Zhang,

Victoria Wong,

Sheila Collins,

Guifan Sun,

Melvin E. Andersen,

Jingbo Pi

Publication year - 2010

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0901608

Subject(s) - oxidative stress , arsenite , sodium arsenite , endocrinology , reactive oxygen species , medicine , intracellular , glutathione , carbohydrate metabolism , arsenic toxicity , biology , antioxidant , insulin , chemistry , biochemistry , arsenic , toxicity , enzyme , organic chemistry

Chronic exposure of humans to inorganic arsenic, a potent environmental oxidative stressor, is associated with incidence of type 2 diabetes (T2D). A key driver in the pathogenesis of T2D is impairment of pancreatic beta-cell function, with the hallmark of beta-cell function being glucose-stimulated insulin secretion (GSIS). Reactive oxygen species (ROS) derived from glucose metabolism serve as one of the metabolic signals for GSIS. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress.

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