Open AccessCommon Genetic Variation, Residential Proximity to Traffic Exposure, and Left Ventricular Mass: The Multi-Ethnic Study of Atherosclerosis
Author(s) -
Victor C. Van Hee,
Sara D. Adar,
Adam A. Szpiro,
R. Graham Barr,
Ana Diez Roux,
David A. Bluemke,
Lianne Sheppard,
Edward A. Gill,
Hossein Bahrami,
Christina L. Wassel,
Michèle M. Sale,
David S. Siscovick,
Jerome I. Rotter,
Stephen S. Rich,
Joel D. Kaufman
Publication year - 2010
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.0901535
Subject(s) - single nucleotide polymorphism , confounding , genetic predisposition , medicine , genetic variation , haplotype , biology , genetics , cardiology , genotype , gene
Elevated left ventricular mass (LVM) is a strong predictor of negative cardiovascular outcomes, including heart failure, stroke, and sudden cardiac death. A relationship between close (< 50 m compared with > 150 m) residential proximity to major roadways and higher LVM has previously been described, but the mechanistic pathways that are involved in this relationship are not known. Understanding genetic factors that influence susceptibility to these effects may provide insight into relevant mechanistic pathways.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom