Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists | Zendy

Gregory J. Howard | Zendy; Jennifer J. Schlezinger | Zendy; Mark E. Hahn | Zendy; Thomas F. Webster | Zendy

Open Access

Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists

Author(s) -

Gregory J. Howard,

Jennifer J. Schlezinger,

Mark E. Hahn,

Thomas F. Webster

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0901312

Subject(s) - aryl hydrocarbon receptor , partial agonist , agonist , pharmacology , chemistry , intrinsic activity , receptor , medicine , biochemistry , transcription factor , gene

Predicting the expected outcome of a combination exposure is critical to risk -assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case of the method of concentration addition. However, the TEF method assumes that individual agents are full aryl hydrocarbon receptor (AhR) agonists with parallel dose-response curves, whereas many mixtures include partial agonists.

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