Flexible Meta-Regression to Assess the Shape of the Benzene–Leukemia Exposure–Response Curve | Zendy

Jelle Vlaanderen | Zendy; Lützen Portengen | Zendy; Nathaniel Rothman | Zendy; Qing Lan | Zendy; Hans Kromhout | Zendy; Roel Vermeulen | Zendy

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Flexible Meta-Regression to Assess the Shape of the Benzene–Leukemia Exposure–Response Curve

Author(s) -

Jelle Vlaanderen,

Lützen Portengen,

Nathaniel Rothman,

Qing Lan,

Hans Kromhout,

Roel Vermeulen

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0901127

Subject(s) - confidence interval , regression , regression analysis , relative risk , statistics , meta analysis , leukemia , medicine , linear regression , mathematics , oncology

Previous evaluations of the shape of the benzene-leukemia exposure-response curve (ERC) were based on a single set or on small sets of human occupational studies. Integrating evidence from all available studies that are of sufficient quality combined with flexible meta-regression models is likely to provide better insight into the functional relation between benzene exposure and risk of leukemia.

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