Computational Model of Steroidogenesis in Human H295R Cells toPredict Biochemical Response to Endocrine-Active Chemicals: Model Developmentfor Metyrapone | Zendy

Michael S. Breen | Zendy; Miyuki Breen | Zendy; Natsuko Terasaki | Zendy; Makoto Yamazaki | Zendy; Rory B. Conolly | Zendy

Open Access

Computational Model of Steroidogenesis in Human H295R Cells toPredict Biochemical Response to Endocrine-Active Chemicals: Model Developmentfor Metyrapone

Author(s) -

Michael S. Breen,

Miyuki Breen,

Natsuko Terasaki,

Makoto Yamazaki,

Rory B. Conolly

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0901107

Subject(s) - metyrapone , endocrine system , endocrinology , chemistry , medicine , hormone

An in vitro steroidogenesis assay using the human adrenocortical carcinoma cell line H295R is being evaluated as a possible screening assay to detect and assess the impact of endocrine-active chemicals (EACs) capable of altering steroid biosynthesis. Data interpretation and their quantitative use in human and ecological risk assessments can be enhanced with mechanistic computational models to help define mechanisms of action and improve understanding of intracellular concentration-response behavior.

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