Cadmium Malignantly Transforms Normal Human Breast Epithelial Cells into a Basal-like Phenotype | Zendy

Lamia BenbrahimTallaa | Zendy; Erik J. Tokar | Zendy; Bhalchandra A. Diwan | Zendy; Anna L. Dill | Zendy; Jean-François Coppin | Zendy; Michael P. Waalkes | Zendy

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Cadmium Malignantly Transforms Normal Human Breast Epithelial Cells into a Basal-like Phenotype

Author(s) -

Lamia BenbrahimTallaa,

Erik J. Tokar,

Bhalchandra A. Diwan,

Anna L. Dill,

Jean-François Coppin,

Michael P. Waalkes

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900999

Subject(s) - cancer research , myoepithelial cell , breast cancer , biology , malignant transformation , estrogen receptor , cancer cell , cancer , pathology , endocrinology , medicine , immunohistochemistry , immunology

Breast cancer has recently been linked to cadmium exposure. Although not uniformly supported, it is hypothesized that cadmium acts as a metalloestrogenic carcinogen via the estrogen receptor (ER). Thus, we studied the effects of chronic exposure to cadmium on the normal human breast epithelial cell line MCF-10A, which is ER-negative but can convert to ER-positive during malignant transformation.

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