Oseltamivir Carboxylate, the Active Metabolite of Oseltamivir Phosphate (Tamiflu), Detected in Sewage Discharge and River Water in Japan | Zendy

Gopal Chandra Ghosh | Zendy; Norihide Nakada | Zendy; Naoyuki Yamashita | Zendy; Hiroaki Tanaka | Zendy

Open Access

Oseltamivir Carboxylate, the Active Metabolite of Oseltamivir Phosphate (Tamiflu), Detected in Sewage Discharge and River Water in Japan

Author(s) -

Gopal Chandra Ghosh,

Norihide Nakada,

Naoyuki Yamashita,

Hiroaki Tanaka

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900930

Subject(s) - effluent , oseltamivir , neuraminidase inhibitor , sewage , sewage treatment , neuraminidase , environmental science , environmental chemistry , veterinary medicine , chemistry , medicine , virology , environmental engineering , virus , covid-19 , disease , infectious disease (medical specialty)

Oseltamivir phosphate (OP; Tamiflu) is a prodrug of the anti-influenza neuraminidase inhibitor oseltamivir carboxylate (OC) and has been developed for the treatment and prevention of both A and B strains of influenza. The recent increase in OP resistance in influenza A virus (H1N1; commonly called "swine flu") has raised questions about the widespread use of Tamiflu in seasonal epidemics and the potential ecotoxicologic risk associated with its use in the event of a pandemic.

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