A Clash of Old and New Scientific Concepts in Toxicity, with Important Implications for Public Health
Author(s) -
John Peterson Myers,
R. Thomas Zoeller,
Frederick S. vom Saal
Publication year - 2009
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.0900887
Subject(s) - precept , medicine , public health , population , toxicology , endocrine system , environmental health , hormone , biology , pathology , philosophy , theology
A core assumption of current toxicologic procedures used to establish health standards for chemical exposures is that testing the safety of chemicals at high doses can be used to predict the effects of low-dose exposures, such as those common in the general population. This assumption is based on the precept that "the dose makes the poison": higher doses will cause greater effects.
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