A Novel Approach Using DNA-Repair–Deficient Chicken DT40 Cell Lines for Screening and Characterizing the Genotoxicity of Environmental Contaminants | Zendy

Kyunghee Ji | Zendy; Toshiaki Kogame | Zendy; Kyungho Choi | Zendy; Xin Wang | Zendy; JinYoung Lee | Zendy; Yoshihito Taniguchi | Zendy; Shunichi Takeda | Zendy

Open Access

A Novel Approach Using DNA-Repair–Deficient Chicken DT40 Cell Lines for Screening and Characterizing the Genotoxicity of Environmental Contaminants

Author(s) -

Kyunghee Ji,

Toshiaki Kogame,

Kyungho Choi,

Xin Wang,

JinYoung Lee,

Yoshihito Taniguchi,

Shunichi Takeda

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900842

Subject(s) - genotoxicity , contamination , dna , dna repair , dna damage , environmental chemistry , environmental science , biology , computational biology , genetics , chemistry , microbiology and biotechnology , toxicity , ecology , organic chemistry

Many bacterial or mammalian cell-based test systems, such as the Ames test, chromosomal aberration assays, or gene mutation assays, are commonly used in developed countries to detect the genotoxicity of industrial chemicals. However, the specificity is generally limited and the sensitivity is not sufficiently high. In addition, most assays cannot provide information on mechanisms of genotoxicity of a given chemical.

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