Open AccessThe Short-Chain Fatty Acid Methoxyacetic Acid Disrupts Endogenous Estrogen Receptor-α–Mediated Signaling
Author(s) -
Derek V. Henley,
Stephanie K. Mueller,
Kenneth S. Korach
Publication year - 2009
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.0900800
Subject(s) - endogeny , estrogen receptor , estrogen , signal transduction , endocrinology , chemistry , receptor , medicine , fatty acid , biology , microbiology and biotechnology , biochemistry , pharmacology , cancer , breast cancer
Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom