Influence of Cobalamin on Arsenic Metabolism in Bangladesh | Zendy

Megan N. Hall | Zendy; Xinhua Liu | Zendy; Vesna Slavkovich | Zendy; Vesna Ilievski | Zendy; Zhongyuan Mi | Zendy; Shafiul Alam | Zendy; Pam FactorLitvak | Zendy; Habibul Ahsan | Zendy; Joseph H. Graziano | Zendy; Mary V. Gamble | Zendy

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Influence of Cobalamin on Arsenic Metabolism in Bangladesh

Author(s) -

Megan N. Hall,

Xinhua Liu,

Vesna Slavkovich,

Vesna Ilievski,

Zhongyuan Mi,

Shafiul Alam,

Pam FactorLitvak,

Habibul Ahsan,

Joseph H. Graziano,

Mary V. Gamble

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900734

Subject(s) - cobalamin , metabolite , urine , arsenic , metabolism , chemistry , toxicity , methyltransferase , confidence interval , methylation , medicine , physiology , biochemistry , vitamin b12 , organic chemistry , gene

Arsenic is a carcinogen to which 35 million people in Bangladesh are chronically exposed. The enzymatic transfer of methyl groups to inorganic As (iAs) generates monomethylarsonic (MMA) and dimethylarsinic acids (DMA) and facilitates urinary As (uAs) elimination. This process is dependent on one-carbon metabolism, a pathway in which folate and cobalamin have essential roles in the recruitment and transfer of methyl groups. Although DMA(V) is the least toxic metabolite, increasing evidence suggests that MMA(III) may be the most cytotoxic and genotoxic As intermediary metabolite.

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