Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens | Zendy

Sofie Christiansen | Zendy; Martin Scholze | Zendy; Majken Dalgaard | Zendy; Anne Marie Vinggaard | Zendy; Marta Axelstad | Zendy; Andreas Kortenkamp | Zendy; Ulla Hass | Zendy

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Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens

Author(s) -

Sofie Christiansen,

Martin Scholze,

Majken Dalgaard,

Anne Marie Vinggaard,

Marta Axelstad,

Andreas Kortenkamp,

Ulla Hass

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900689

Subject(s) - offspring , vinclozolin , anogenital distance , antiandrogens , physiology , teratology , androgen , toxicology , phthalate , xenoestrogen , sexual differentiation , antiandrogen , biology , gestation , endocrinology , toxicity , medicine , pregnancy , fetus , chemistry , pesticide , in utero , hormone , genetics , cancer , breast cancer , agronomy , organic chemistry , estrogen receptor , gene

By disrupting the action of androgens during gestation, certain chemicals present in food, consumer products, and the environment can induce irreversible demasculinization and malformations of sex organs among male offspring. However, the consequences of simultaneous exposure to such chemicals are not well described, especially when they exert their actions by differing molecular mechanisms.

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