Central Neuroplasticity and Decreased Heart Rate Variability after Particulate Matter Exposure in Mice | Zendy

Hai Pham | Zendy; Ann C. Bonham | Zendy; Kent E. Pinkerton | Zendy; Chao-Yin Chen | Zendy

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Central Neuroplasticity and Decreased Heart Rate Variability after Particulate Matter Exposure in Mice

Author(s) -

Hai Pham,

Ann C. Bonham,

Kent E. Pinkerton,

Chao-Yin Chen

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900674

Subject(s) - heart rate variability , medicine , heart rate , endocrinology , autonomic nervous system , chemistry , sinoatrial node , electrophysiology , depolarization , vagus nerve , cardiology , anesthesia , blood pressure , stimulation

Epidemiologic studies show that exposure to fine particulate matter [aerodynamic diameter < or = 2.5 microm (PM(2.5))] increases the total daily cardiovascular mortality. Impaired cardiac autonomic function, which manifests as reduced heart rate variability (HRV), may be one of the underlying causes. However, the cellular mechanism(s) by which PM(2.5) exposure induces decreased HRV is not known.

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