Basis of the Massachusetts Reference Dose and Drinking Water Standard for Perchlorate
Author(s) -
Tsedash Zewdie,
C. Mark Smith,
Michael S. Hutcheson,
Carol Rowan West
Publication year - 2009
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.0900635
Subject(s) - perchlorate , environmental health , environmental science , environmental chemistry , medicine , chemistry , ion , organic chemistry
Perchlorate inhibits the uptake of iodide in the thyroid. Iodide is required to synthesize hormones critical to fetal and neonatal development. Many water supplies and foods are contaminated with perchlorate. Exposure standards are needed but controversial. Here we summarize the basis of the Massachusetts (MA) perchlorate reference dose (RfD) and drinking water standard (DWS), which are considerably lower and more health protective than related values derived by several other agencies. We also review information regarding perchlorate risk assessment and policy.
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