Racial Differences in Paraoxonase-1 (PON1): A Factor in the Health of Southerners? | Zendy

Kimberly A. Davis | Zendy; J. Allen Crow | Zendy; Howard W. Chambers | Zendy; Edward C. Meek | Zendy; Janice E. Chambers | Zendy

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Racial Differences in Paraoxonase-1 (PON1): A Factor in the Health of Southerners?

Author(s) -

Kimberly A. Davis,

J. Allen Crow,

Howard W. Chambers,

Edward C. Meek,

Janice E. Chambers

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0900569

Subject(s) - paraoxonase , pon1 , aryldialkylphosphatase , arylesterase , cotinine , medicine , population , endocrinology , demography , genotype , nicotine , biology , biochemistry , environmental health , oxidative stress , sociology , gene

The southern United States (excluding Florida) has the highest age-adjusted rate of cardiovascular disease (CVD) in the country, with African Americans having a higher prevalence of CVD than Caucasians. Paraoxonase-1 (PON1), an enzyme associated with high-density lipoprotein particles, participates both in the hydrolysis of oxidized lipids (thus protecting against atherosclerosis) and in the hydrolysis of organophosphates. Higher paraoxonase activity has been associated with lower risk of atherosclerosis.

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