Molecular Population Genetics of Human CYP3A Locus: Signatures of Positive Selection and Implications for Evolutionary Environmental Medicine | Zendy

Xiaoping Chen | Zendy; Haijian Wang | Zendy; Gangqiao Zhou | Zendy; Xiumei Zhang | Zendy; Xiaojia Dong | Zendy; Lianteng Zhi | Zendy; Jin Li | Zendy; Fuchu He | Zendy

Open Access

Molecular Population Genetics of Human CYP3A Locus: Signatures of Positive Selection and Implications for Evolutionary Environmental Medicine

Author(s) -

Xiaoping Chen,

Haijian Wang,

Gangqiao Zhou,

Xiumei Zhang,

Xiaojia Dong,

Lianteng Zhi,

Jin Li,

Fuchu He

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800528

Subject(s) - biology , genetics , locus (genetics) , population genetics , evolutionary biology , human evolutionary genetics , selection (genetic algorithm) , population , computational biology , gene , phylogenetics , medicine , environmental health , computer science , artificial intelligence

The human CYP3A gene cluster codes for cytochrome P450 (CYP) subfamily enzymes that catalyze the metabolism of various exogenous and endogenous chemicals and is an obvious candidate for evolutionary and environmental genomic study. Functional variants in the CYP3A locus may have undergone a selective sweep in response to various environmental conditions.

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