Decreased PM 10 Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in p53 , p21 , and CCND1 Modify This Effect | Zendy

Medea Imboden | Zendy; Joel Schwartz | Zendy; Christian Schindler | Zendy; Ivan Curjuric | Zendy; Wolfgang Berger | Zendy; Sally L.J. Liu | Zendy; Erich W. Russi | Zendy; Ursula AckermannLiebrich | Zendy; Thierry Rochat | Zendy; Nicole ProbstHensch | Zendy

Open Access

Decreased PM ₁₀ Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in p53 , p21 , and CCND1 Modify This Effect

Author(s) -

Medea Imboden,

Joel Schwartz,

Christian Schindler,

Ivan Curjuric,

Wolfgang Berger,

Sally L.J. Liu,

Erich W. Russi,

Ursula AckermannLiebrich,

Thierry Rochat,

Nicole ProbstHensch

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800430

Subject(s) - medicine , confidence interval , cohort , population , prospective cohort study , spirometry , physiology , environmental health , asthma

Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution.

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