Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein–Coupled Estrogen Receptor | Zendy

Adil Bouskine | Zendy; Marielle Nebout | Zendy; Françoise Brücker-Davis | Zendy; Mohamed Benahmed | Zendy; Patrick Fénichel | Zendy

Open Access

Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein–Coupled Estrogen Receptor

Author(s) -

Adil Bouskine,

Marielle Nebout,

Françoise Brücker-Davis,

Mohamed Benahmed,

Patrick Fénichel

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800367

Subject(s) - estrogen receptor , cell growth , protein kinase a , chemistry , creb , diethylstilbestrol , medicine , endocrinology , endocrine disruptor , estrogen , biology , kinase , transcription factor , biochemistry , hormone , endocrine system , cancer , breast cancer , gene

Fetal exposure to environmental estrogens may contribute to hypofertility and/or to testicular germ cell cancer. However, many of these xenoestrogens have only a weak affinity for the classical estrogen receptors (ERs,) which is 1,000-fold less potent than the affinity of 17beta-estradiol (E(2)). Thus, several mechanisms have been suggested to explain how they could affect male germ cell proliferation at low environmental relevant concentrations.

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