Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a β-Arrestin–Dependent Manner via Activation of RAS | Zendy

Jinju Li | Zendy; Andrew J. Ghio | Zendy; SeungHyun Cho | Zendy; Constance Brinckerhoff | Zendy; Sidney A. Simon | Zendy; Wolfgang Liedtke | Zendy

Open Access

Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a β-Arrestin–Dependent Manner via Activation of RAS

Author(s) -

Jinju Li,

Andrew J. Ghio,

SeungHyun Cho,

Constance Brinckerhoff,

Sidney A. Simon,

Wolfgang Liedtke

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800311

Subject(s) - matrix metalloproteinase , small interfering rna , microbiology and biotechnology , kinase , biology , gene silencing , immunology , gene , chemistry , genetics , transfection

Diesel exhaust particles (DEPs) are globally relevant air pollutants that exert a detrimental human health impact. However, mechanisms of damage by DEP exposure to human respiratory health and human susceptibility factors are only partially known. Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio)pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs.

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