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Studies have demonstrated ubiquitous human exposure to persistent organic pollutants (POPs) such as p,p'-diphenyldichloroethene (DDE) and polychlorinated biphenyls (PCBs). Although there is considerable evidence that POP exposures are associated with prevalent diabetes, these studies do not establish causality because the cross-sectional study design does not allow for assessment of temporality of the exposure-disease association. Prospective studies, however, have been lacking.

Organochlorine Exposure and Incidence of Diabetes in a Cohort of Great Lakes Sport Fish Consumers