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Lead is known to be a health hazard to the human brain and nervous system based on data from epidemiologic studies. However, few studies have examined the mechanism or biochemical changes caused by lead in the human brain, although recently some have used magnetic resonance spectroscopy (MRS) to test brain metabolism in vivo.

A Proton Magnetic Resonance Spectroscopy Study of the Chronic Lead Effect on the Basal Ganglion and Frontal and Occipital Lobes in Middle-Age Adults