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Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh
Author(s) -
Megan N. Hall,
Xinhua Liu,
Vesna Slavkovich,
Vesna Ilievski,
J. Richard Pilsner,
Shafiul Alam,
Pam FactorLitvak,
Joseph H. Graziano,
Mary V. Gamble
Publication year - 2009
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.1289/ehp.0800164
Subject(s) - cobalamin , homocysteine , cysteine , arsenic , metabolism , methylation , urine , cystathionine beta synthase , chemistry , metabolite , medicine , endocrinology , biochemistry , biology , vitamin b12 , enzyme , organic chemistry , gene
Approximately 35 million people in Bangladesh are chronically exposed to inorganic arsenic (InAs) in drinking water. Methylation of InAs to monomethylarsonic (MMA) and dimethylarsinic acids (DMA) relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic (uAs) elimination.

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