Distinct Contributions of JNK and p38 to Chromium Cytotoxicity and Inhibition of Murine Embryonic Stem Cell Differentiation | Zendy

Liang Chen | Zendy; Jerald L. Ovesen | Zendy; Alvaro Puga | Zendy; Ying Xia | Zendy

Open Access

Distinct Contributions of JNK and p38 to Chromium Cytotoxicity and Inhibition of Murine Embryonic Stem Cell Differentiation

Author(s) -

Liang Chen,

Jerald L. Ovesen,

Alvaro Puga,

Ying Xia

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800157

Subject(s) - p38 mitogen activated protein kinases , mapk/erk pathway , kinase , cytotoxicity , reactive oxygen species , microbiology and biotechnology , chemistry , mitogen activated protein kinase , embryoid body , c jun , biology , embryonic stem cell , biochemistry , transcription factor , in vitro , adult stem cell , gene

Potassium dichromate [Cr(VI)] is a widespread environmental toxicant responsible for increased risk of several human diseases. Cr(VI) exposure leads to activation of mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK)1/2, p38, and extracellular-signal regulated kinase (ERK)1/2.

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