Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats | Zendy

Aimen K. Farraj | Zendy; Najwa Haykal-Coates | Zendy; Darrell W. Winsett | Zendy; Mehdi S. Hazari | Zendy; Alex P. Carll | Zendy; William H. Rowan | Zendy; Allen D. Ledbetter | Zendy; Wayne E. Cascio | Zendy; Daniel L. Costa | Zendy

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Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats

Author(s) -

Aimen K. Farraj,

Najwa Haykal-Coates,

Darrell W. Winsett,

Mehdi S. Hazari,

Alex P. Carll,

William H. Rowan,

Allen D. Ledbetter,

Wayne E. Cascio,

Daniel L. Costa

Publication year - 2008

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800129

Subject(s) - inhalation , medicine , inhalation exposure , cardiology , heart rate , cardiac function curve , blood pressure , endocrinology , heart failure , anesthesia

Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease, including hypertension. PM inhalation causes several adverse changes in cardiac function that are reflected in the electrocardiogram (ECG), including altered cardiac rhythm, myocardial ischemia, and reduced heart rate variability (HRV). The sensitivity and reliability of ECG-derived parameters as indicators of the cardiovascular toxicity of PM in rats are unclear.

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