Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T 4 and TSH | Zendy

Eva D. McLanahan | Zendy; Melvin E. Andersen | Zendy; Jerry L. Campbell | Zendy; Jeffrey W. Fisher | Zendy

Open Access

Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T ₄ and TSH

Author(s) -

Eva D. McLanahan,

Melvin E. Andersen,

Jerry L. Campbell,

Jeffrey W. Fisher

Publication year - 2009

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.0800111

Subject(s) - thyroid , endocrinology , medicine , iodide , hormone , perchlorate , sodium iodide symporter , hypothalamic–pituitary–thyroid axis , iodine , chemistry , symporter , biology , thyroid hormones , biochemistry , transporter , ion , organic chemistry , gene

Perchlorate (ClO4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO4(-) competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic-pituitary-thyroid (HPT) axis homeostasis in rodents.

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